Clinical Research
Peer-reviewed studies supporting OmegaBrite’s EPA-rich omega-3 formulations, prepared for healthcare professionals.
Evidence type
Product
19 studies
Clinical
Omega-3 plasma levels and clinical outcomes in the OATS studies
Arnold et al.
· 2017
· J Child & Adolescent Psychopharmacology
27(3):223-233
—The Ohio State University
Study population: 95 youth
RCT analysis
2 g/d raised EPA blood levels ~7-fold; EPA increase mediated improvement
Clinical
Body weight affects omega-3 PUFA accumulation in youth (post-hoc)
Christian et al.
· 2017
· PLoS ONE
12(4):e0173087
—The Ohio State University
Study population: 95 youth
Post-hoc RCT analysis
Body weight inversely related to omega-3 accumulation (supports weight-based dosing)
Clinical
RCT of IF-PEP and omega-3 in youth with subsyndromal bipolar disorder
Fristad et al.
· 2015
· J Child & Adolescent Psychopharmacology
25(10):764-774
—The Ohio State University
Study population: 23 youth (ages 7-14)
Pilot RCT (2x2), 12 wk
Combined treatment improved depressive symptoms vs placebo
Clinical
Pilot RCT of omega-3 and IF-PEP for children/adolescents with depression
Fristad et al.
· 2019
· J Clinical Child & Adolescent Psychology
48(S1):S105-S118
—The Ohio State University
Study population: 72 youth with depression
Pilot RCT (2x2)
Omega-3 monotherapy effect on depression (d=0.42); favorable remission
Clinical
Long-term outcomes of youth from the OATS studies
Fristad et al.
· 2021
· J Affective Disorders
281:24-32
—The Ohio State University
Study population: 38 of 95 families
Naturalistic follow-up
Mood/executive/global functioning remained better than RCT baseline
Preclinical — animal/lab data only. Does not establish human efficacy.
Preclinical
Dietary LPC-bound n-3 LCPUFA protects against neonatal brain injury in mice
Hermans et al.
· 2024
· Nutrients
16(14):2252
—Utrecht / Aker BioMarine
Study population: 9-day-old mice
Neonatal mouse model
Reduced gray/white-matter injury & oxidative stress; did not improve functional deficits
Clinical
Omega-3 supplementation and loneliness-related memory problems
Jaremka et al.
· 2014
· Psychosomatic Medicine
76(8):650-658
—The Ohio State University
Study population: 138 adults
Secondary analysis of RCT
Omega-3 buffered loneliness-related verbal memory effects
Meta-analysis
Long-chain omega-3 PUFAs for anxiety/depression: systematic review & meta-analysis
Kelaiditis, Gibson, Dyall
· 2023
· Prostaglandins, Leukotrienes & Essential Fatty Acids
192:102572
—University of Roehampton
Study population: 10 RCTs, 1426 participants
Systematic review & meta-analysis
EPA-rich (>=60% EPA) reduces depression severity
Clinical
Omega-3 supplementation lowers inflammation and anxiety in medical students
Kiecolt-Glaser et al.
· 2011
· Brain, Behavior, and Immunity
25(8):1725-1734
—The Ohio State University
Study population: 68 medical students
Double-blind RCT, 12 wk
~20% lower anxiety; lower IL-6 vs placebo
Clinical
Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults
Kiecolt-Glaser et al.
· 2012
· Brain, Behavior, and Immunity
26(6):988-995
—The Ohio State University
Study population: 138 middle-aged/older adults
Double-blind RCT, 4 mo
Lower serum IL-6 vs placebo
Clinical
Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: an RCT
Kiecolt-Glaser et al.
· 2013
· Brain, Behavior, and Immunity
28:16-24
—The Ohio State University
Study population: 106 adults
Double-blind RCT, 4 mo
F2-isoprostanes ~15% lower; telomere length increased as n-6:n-3 ratio fell (ratio finding)
Clinical
Omega-3 supplementation and stress reactivity of cellular aging biomarkers
Madison et al.
· 2021
· Molecular Psychiatry
26(7):3034-3042
—The Ohio State University
Study population: 138 midlife adults
Ancillary substudy RCT
Lower overall cortisol & IL-6 during a lab stressor
Preclinical — animal/lab data only. Does not establish human efficacy.
Preclinical
Mfsd2a is a transporter for the essential omega-3 fatty acid DHA
Nguyen et al.
· 2014
· Nature
509(7501):503-506
—Duke-NUS
Study population: Mice
Mouse knockout / cell
MFSD2A transports omega-3 into the brain only in the LPC form
Preclinical — animal/lab data only. Does not establish human efficacy.
Preclinical
Dietary DHA as lysophosphatidylcholine enriches brain DHA and improves memory in adult mice
Sugasini et al.
· 2017
· Scientific Reports
7:11263
—University of Illinois Chicago
Study population: Adult mice
Mouse
LPC-DHA raised brain DHA >2x and improved memory; free DHA did not
Clinical
Omega-3 and improved parent-rated executive function in youth with mood disorders
Vesco et al.
· 2018
· J Child Psychology & Psychiatry
59(6):628-636
—The Ohio State University
Study population: 95 youth
Secondary analysis of 2 RCTs
Improved parent-rated executive function vs placebo
Clinical (open-label pilot)
Omega-3 fatty acid monotherapy for pediatric bipolar disorder
Wozniak et al.
· 2007
· European Neuropsychopharmacology
2007
—Massachusetts General Hospital / Harvard
Study population: 20 youth (ages 6-17)
Open-label pilot, 8 wk
Modest YMRS reduction (label: open-label, not RCT)
Preclinical — animal/lab data only. Does not establish human efficacy.
Preclinical
Dietary LPC-EPA enriches both EPA and DHA in the brain
Yalagala et al.
· 2019
· Journal of Lipid Research
60(3):566-578
—University of Illinois Chicago
Study population: Mice
Mouse
LPC-EPA raised brain EPA >100x and DHA 2x; also raised EPA/DHA in retina
Clinical
PEP and omega-3 improve co-occurring behavioral problems in youth with depression
Young et al.
· 2017
· J Abnormal Child Psychology
45(5):1025-1037
—The Ohio State University
Study population: 72 youth with depression
Pilot RCT
Combined PEP+omega-3 improved behavior-problem trajectories
Clinical (methods)
Predicting enrollment in two RCTs of nonpharmacologic interventions for youth
Young et al.
· 2018
· J Affective Disorders
235:368-373
—The Ohio State University
Study population: 119 screened
Methods (enrollment analysis)
Enrollment predictors (supportive/contextual, not efficacy)
